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Selected Recent Publications
1. Zhang, S.; Hu, Z.; Tanji, H.; Jiang, S.; Das, N.; Li, J.; Sakaniwa, K.; Jin, J.; Bian, Y.; Ohto, U.; Shimizu, T.;
*Yin, H. “Small Molecule Inhibition of TLR8 through Stabilization of Its Resting State”,
Nat. Chem. Biol.
2018,
14, 58-64 (cover article; featured in
C&EN
“Latest News”).
2. Hu, Z.; Tanji, H.; Jiang, S.; Zhang, S.; Koo, K.; Chan, J.; Sakaniwa, K.; Ohto, U.; Candia, A.; Shimizu, T.;
*Yin, H. “Small Molecule TLR8 Antagonists via Structure-Based Rational Design”,
Cell Chem. Biol.
2018, 25,
1286-1291(cover article).
3. Bhattacharyya, S.; Wang, W.; Qin, W.; Cheng, K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.; Tamaki, Z.;
*Yin, H.; *Varga, J. “TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skin and Lung”,
JCI Insight
2018,
3, e98850 (featured in “
News & Views”
Nat. Rev. Rheumatol.
2018,
14,
564-566).
4. Zhang, L.; Shi, L.; Soars, S. M.; Kamps, J.;
*Yin, H. “Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Anti-Inflammatory and Anti-Cancer Properties”,
J. Med. Chem.
2018,
61,
5881-5899.
5. Zhang, L.; Dewan, V.;
*Yin, H. “Discovery of Small Molecules as Multi-TLR Agonists with Proinflammatory and Anticancer Activities”,
J. Med. Chem.
2017,
60,
5029-5044.
6. Smith, C. E.; Soti, S.; Jones, T. A.; Nakagawa, A.; Xue, D.;
*Yin, H. “NSAIDs are Caspase Inhibitors”,
Cell Chem. Biol.
2017,
24,
281-292 (featured in “
Concentrates”
C&EN
2017,
95(10), 10; NIH
Research Matters;
The Sun; Daily Mail).
7. Das, N.; Dewan, V.; Grace, P. M.; Gunn, R. J.; Tamura, R.; Tzarum, N.; Watkins, L. R.; Wilson, I. A.;
*Yin, H. “HMGB-1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia”,
Cell Rep.
2016,
17, 1128-1140.
8.
*Yin, H.; Flynn, A.D. “Drugging Membrane Protein Interactions”,
Annu. Rev. Biomed. Eng.
2016,
18, 51-76.
9. Wang, T.; de Jesus, A.; *Shi, Y.;
*Yin, H.; “Pyridoxamine is a substrate of the energy-coupling factor transporter HmpT",
Cell Discov.
2015,
1, 15014.
10. Daniele, S. G.; Beraud, D.; Davenport, C.; Cheng, K.;
*Yin, H.; *Maguire-Zeiss, K. A.; “Activation of MyD88-Dependent TLR
1/2 Signaling by Misfolded α-Synuclein, a Protein Linked to Neurodegenerative Disorders”,
Sci. Signal.
2015,
8, ra45 (highlighted in “
This Week in Science”
Science
2015,
348, 769; Podcast: Maguire-Zeiss, K. A.; Daniele, S. G.;
Yin, H.; VanHook, A. M.;
Sci. Signal.
2015,
8, pc12; feature story by the Xinhua News Agency).
11. Cheng, K.; Gao, M.; Godfroy, J. I. III; Brown, P. N.; Kastelowitz, N.;
*Yin, H.; “Specific Activation of the TLR1-TLR2 Heterodimer by Small-molecule Agonists”,
Sci. Adv.
2015,
1, e
1400139 (featured in “
Science & Technology”
C&EN
2015,
93(15), 39-40).
12. Smith, C. E.; Wang, X. H.;
*Yin, H.; “Caspases Come Together Over LPS”,
Trends Immunol.
2015,
36, 59-61.
13. Yang, H.; Chen, Y. Z.; Zhang, Y.; Wang, X. H.; Zhao, X.; Godfroy, J. I.; Liang, Q.; Zhang, M.; Zhang, T.; Yuan, Q.; Royal, M. A.; Driscoll, M.; Xia, N. S.;
Yin, H.; Xue, D. “A Lysine-Rich Motif in the Phosphatidylserine Receptor PSR-1 Mediates Recognition and Removal of Apoptotic Cells”,
Nat. Commun.
2015,
6, 5717.
14. Csakai, A.; Smith, C.; Davis, E.; Martinko, A.; Coulup, S.;
*Yin, H. “Saccharin Derivatives as Inhibitors of Interferon-Mediated Inflammation”,
J. Med. Chem.
2014,
57,
5348-5355(cover article).
15. Wang, X. H.; Grace, P. M.; Pham, M. N.; Cheng, K.; Strand, K. A.; Smith, C. E.; Li, J.; Watkins, L. R.;
*Yin, H. “Rifampin Inhibits Toll-like Receptor 4 Signaling by Targeting Myeloid Differentiation Protein 2 and Attenuates Neuropathic Pain”,
FASEB J.
2013,
27,
2713-2722.
16. Wang, X. H.; Smith, C.;
*
Yin,
H. “Targeting Toll-Like Receptors with Small Molecule Agents”,
Chem. Soc. Rev.
2013,
42,
4859-4866 (cover article).
17. Brown, P. N.;
*Yin, H. “PNA-Based MicroRNA Inhibitors Elicit Anti-Inflammatory Effects in Microglia Cells”,
Chem. Commun.
2013
, 49,
4415-4417 (
2013 Emerging Investigatorsissue).
18. Morton, L. A.; Saludes, J. P.; Beninson, L.; Chapman, E. R.; Fleshner, M.;
*Yin, H. “MARCKS-ED Peptide as a Membrane Curvature Sensor”,
ACS Chem. Biol.
2013
, 8, 218-225.
19. Cheng, K.; Wang, X. H.; Zhang, S.;
*Yin, H. “Discovery of Small-Molecules that Inhibit the Protein Complex of Toll-Like Receptor 1 and 2”,
Angew. Chem. Int. Ed.
2012,
51,
12246-12249 (cover article; featured in “
Science & Technology Concentrates”
C&EN
2012,
90(35), 33).
20. Saludes, J. P.; Morton, L. A.; Ghosh, N.; Beninson, L.; Chapman, E. R.; Fleshner, M.;
*Yin, H. “Detection of Highly Curved Membrane Surfaces Using a Cyclic Peptide Derived from Synaptotagmin-I”,
ACS Chem. Biol.
2012
, 7,
1629-1635.
21. Wang, X. H.; Loram, L. C.; Ramos, K.; de Jesus, A.; Thomas, J.; Cheng, K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.;
*Yin,
H. “Morphine Activates Neuroinflammation in a Parallel Manner to Endotoxin”,
Proc. Natl. Acad. Sci. U. S. A.
2012,
109,
6325-6330
(highlighted in “
Research Highlights This Week”
Nature
2012,
484, 419; “
This Week in PNAS”; Sci. Signal. Editors’ Choice; featured on the website of
the Association of American Universities; recommended by the
Faculty of 1000 website).
22. Chavez, S. A.; Martinko, A. J.; Lau, C.; Pham, M. N.; Cheng, K.; Mollnes, T. E.;
*Yin,
H. “Development of β–Amino Alcohol Derivatives that Inhibit TLR4-Mediated Inflammatory Response as Potential Antiseptics”,
J. Med. Chem.
2011,
54,
4659-4669 (headlined in
Global Medical Discovery).
23. Cheng, K.; Wang, X. H.;
*Yin, H. “Small Molecule Inhibitors of the TLR3/dsRNA Complex”,
J. Am. Chem. Soc.
2011,
133,
3764-3767.
24.
*Yin, H. “Exogenous Agents that Target Transmembrane Domains of Proteins”,
Angew. Chem. Int. Ed.
2008,
47,
2744-2752 (cover article).
25.
Yin,
H.; Slusky, J. S; Berger, B. W.; Walters, R. S.; Vilaire, G.; Litvinov, R. I.; Lear, J. D.; Caputo, G. A.; Bennett, J. S.; DeGrado, W. F. “Computational Design of Peptides that Target Transmembrane Helices”,
Science
2007,
315,
1817-1822 (featured in “
News of the Week”
C&EN
2007,
85, 11; “News and Views”
Nat. Biotech.
2007,
25, 646; and “Editors’ Choice”
Sci. Signal.
2007,
2007, tw119).
