Research Interests
Current research focuses on design and application of novel nanocarriers and polymer-based systems as drug delivery systems. In recent studies, the new modified polymer-based systems are developed to enhance the transfection and expression efficiency of DNA or siRNA in EGFR-overexpressing tumor cell. We also study utilizing nanotechnology to improve the solubility and bioavailability of poorly soluble drugs, and give these drugs specific characteristics like targeting, sustained or controlled release characteristics. We seek ways to use these nano delivery systems to improve the delivery efficiency of drugs, thus achieving the significant treatment effect for therapy of major diseases such as cancer.
Selected Publications
1.Jun Li, Shengnan Li, Songyun Xia, Jinfeng Feng, Yanli Hao*, Lei Chen*, Xiaoning Zhang*. 2015. Enhanced transfection efficiency and targeted delivery of self-assembling h-R3-dendriplexes in EGFR-overexpressing tumor cells. Oncotarget, Early Online, 6: 26177-91.
2.Jun Li, Lei Chen, Nan Liu, Shengnan Li, Yanli Hao*, Xiaoning Zhang*. 2015. EGF-coated nano-dendriplexes for tumor targeted nucleic acid delivery in vivo. Drug Delivery, 25:1-8.
3.Yanli Hao*, Lan Wang, Jun Li, Nan Liu, Jinfeng Feng, Mojiao Zhao, Xiaoning Zhang*. 2015. Enhancement of solubility, transport across MDCK monolayer and oral absorption of pranlukast by preparing pranlukast-phospholipid complex. J. Biomedical Nanotechnology, 11(3): 469-477(9)
4.Anil Kumar, Fei Chen, Anbu Mozhi,Xu Zhang, Yuanyuan Zhao, Xiangdong Xue, Yanli Hao, Xiaoning Zhang, and Xing-Jie Liang*. 2013. Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation. Nanoscale, 5:8307-8325.
5.Zhe Yin, Nan Liu, Mingshu Ma, Lan Wang, Xing-Jie Liang, Yanli Hao*, Xiaoning Zhang*. 2012. A novel EGFR-targeted gene delivery system based on complexes self-assembled by EGF, DNA and activated PAMAM dendrimers, In J Nanomedicine 7, pp 4625-4635.
6.Nan Liu, Yanli Hao*, Zhe Yin, Mingshu Ma, Lan Wang, Xiaoning Zhang*. 2012. Self-Assembled Human Serum Albumin-Coated Complexes for Gene Delivery with Improved Transfection. Die Pharmazie, 67(2): 174-181.
Mingshu Ma, Yanli Hao*, Nan Liu, Zhe Yin, Lan Wang, Xing-Jie Liang, Xiaoning Zhang*. 2012. A novel lipid-based nano-micelle of docetaxel: evaluated antitumor efficiency and biodistribution with optical imaging in vivo. In J Nanomedicine,7, pp 3389-3398.
7.Lan Wang, Yanli Hao*, Nan Liu, Zhe Yin, Mingshu Ma, Xiaoning Zhang*. 2012. Enhance the dissolution rate and oral bioavailability of pranlukast by preparing nanosuspensions with high-pressure homogenizing method. Drug Development and Industrial Pharmacy, 38(11):1381-1389.
8.Chunlei Li, Jingxia Cui, Yingui Li, Caixia Wang, Yanhui Li, Lan Zhang, Li Zhang, Wenmin Guo, Jinxu Wang, Hongwu Zhang, Yanli Hao, Yongli Wang. 2008. Copper ion-mediated liposomal encapsulation of mitoxantrone:The role of anions in drug loading, retention and release. Eur. J Pharm. Sci, 34(4-5):333-344.
Jingxia Cui, Chunlei Li, Yanhui Li, Caixia Wang, Li Zhang, Lan Zhang, Yanli Hao,Yongli Wang. 2007. Direct comparison of two pegylated liposomal doxorubicin formulations: Is AUC predictive for toxicity and efficacy? J Controlled Release, 118(2):204-215.
9.Aijun Hao, Yingjie Deng, Tiefu Li, Xubin Suo, Yanhai Cao, Yanli Hao, Yong Zhang. 2006. Degradation kinetics of fluorouracil-acid-dextran conjugate in aqueous solution. Drug Development and Industrial Pharmacy, 32(6):757-763.
10.Yanli Hao, Yingjie Deng, Yan Chen, Kezhan Wang, Aijun Hao and Yong Zhang. 2005. In vitro cytotoxicity, in vivo biodistribution and anti-tumor effect of PEGlyated liposome containing topotecan. J Pharmacy and Pharmacology, 57: 1279-1287.
11.Yanli Hao, Yingjie Deng, Yan Chen, Xiumin Wang, Haijun Zhong and Xubin Suo. 2005. In-Vitro and In-Vivo Studies of Different Liposomes Containing Topotecan. Archives of Pharmacal Research, 28(5): 626-635.
12.Yanli Hao, Yingjie Deng, Yan Chen and Youcai Hu. Synthesis 3-4-2-hydroxyl-(1-methyl ethylamine) propyl oxygen}phenyl}propionic acid cetylester as Potential Ligand for Liposome Targeting to Ischemic Myocardium. Chinese Chemical Letters, 16(8):1004-1006.
13.Yan Chen, Yingjie Deng, Yanli Hao. 2005. Surface modification of liposomes for selective cardiomyocytes targeting in vitro. Die Pharmazie, 60(3): 238-240.
14.Yan Chen, Yingjie Deng, Yanli Hao, Aijun Hao, Haijun Zhong and Xiumin Wang. 2005. Uptake of liposomes by cultured cardiomyocytes. Die Pharmazie, 60(11):844-848.
