(1) R&D of novel dosage forms and technologies: to improve bioavailability following oral administration or transdermal drug delivery by sustained or controlled release; formulation optimization of liposomes based on molecular interaction analysis between drug and carriers; pharmaceutical development and application of 3D printing technologies; rapid and non-destructive detection and control of drug processing with NIR.
(2) TCM-related research: to investigate the active components and mechanism of TCM preparations and to develop new products based on chemical analysis, omics research and activity evaluation. The antifungal, gynecological and anti-ageing projects received funding from the Tsinghua-KU Leuven collaboration, Horizon 2020 and China MOST.
(3) ADME & DMPK: to investigate ADME & DMPK of small molecules, active compounds of TCM and new dosage forms, especially the discovery of metabolites based on LC/MS analysis, data development and chemical synthesis.
Based on the research above, ten Chinese patents and one international patent have been applied for, and six have been authorization granted.
Monographs
1. Guoan Luo, Yiming Wang, Qionglin Liang,
Qingfei Liu. System biology for TCM, John Wiley Press, 2012 (English version)
2. Guoan Luo, Yiming Wang, Qionglin Liang,
Qingfei Liu. System biology for TCM, Science Press, 2011 (Chinese version)
3. Novel dosage forms. Editor, Chemical Industry Press, 2003
Papers
1. Walter Luyten, Peter Antal, Bart P. Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi,
Qingfei Liu, Patricia Martorell, Andres Metspalu, Andres Metspalu, Markus Perola, Michael Ristow, Nadine Saul, Liliane Schoofs, Karsten Siems, Liesbet Temmerman, Tina Smets, Alicja Wolk, Suresh I.S. Rattan. Ageing with elegans: a research proposal to map healthspan pathways.
Biogerontology, 2016, 17(4): 771-782
2. Donglin He, Shuhui Yin, Fuguo Han, Jingjie Zhu, Zhiyuan Tong,
Qingfei Liu. Pharmacokinetics and Tissue Distribution of Two Novel Isomeric Anticancer Platinum Compounds.
Drug Dev Ind Pharm, 2016, in press
3. Zhengguang Li, Rui Zhang, Xiuping Wang, Xiaofei Hu, Yuguo Chen,
Qingfei Liu. Simultaneous determination of seven ginsenosides in rat plasma by high performance liquid chromatography coupled to time-of-flight mass spectrometry: Application to pharmacokinetics of Shenfu injection.
Biomed Chromatogr, 2015, 29(2): 167-175
4. Jun Shi, Wenjuan Cong, Yiming Wang,
Qingfei Liu, Guoan Luo. Synergistic Effect and Mechanism of Cineole and Terpineol on in vitro Transdermal Delivery of Huperzine A from Microemulsions.
Iran J Pharm Res. 2013, 12(2):271-80
5.
Qingfei Liu, Yun Shi, Tuo Guo, Yong Wang, Wenjuan Cong, Jingjie Zhu. Metabolite discovery of helicidum in rat urine with XCMS based on the data of ultra performance liquid chromatography coupled to time-of-flight mass spectrometry.
J Chromatogr B, 2012, 907, 146-153
6．
Qingfei Liu, Walter Luyten, Klaartje Pellens, Yiming Wang, Wei Wang, Karin Thevissen, Qionglin Liang, Bruno P.A. Cammue, Liliane Schoofs, Guoan Luo. Screening for Antifungal Plants from Chinese Traditional and Folk Medicines,
J Ethnopharm, 2012, 143(3): 772-778
7. Wenjuan Cong, Jun Shi, Yiming Wang, Qingfei Liu, Guoan Luo. Molecular Mechanism Study on the Cumulative Cardiotoxicity of a Pirarubicin Liposome Powder.
Talanta, 2012, 89: 91-98
8. Jun Shi, Wenjuan Cong, Yiming Wang,
Qingfei Liu, Guoan Luo. Microemulsion-based Patch for Transdermal Delivery of Huperzine A and Ligustrazine Phosphate.
Drug Dev Ind Pharm, 2012, 38(6): 752-761
9．Jun Shi,
Qingfei Liu, Yiming Wang, Guoan Luo. Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats.
Pharmacol Biochem Beh, 2010, 96: 449-453
10．Juan Lu, Changmei Cheng, Xinge Zhao,
Qingfei Liu, Ping Yang, Yiming Wang, Guoan Luo. PEG-scutellarin Prodrugs: Synthesis and
Efficacy Studies.
Eur J Med Chem, 2010, 45(5): 1731-1738
11. Wenjuan Cong,
Qingfei Liu, Xi Chen, Rong Gao, Juan Lu, Yiming Wang, Guoan Luo. Characterization and Pharmacokinetics of a Novel Pirarubicin Liposome Powder.
Drug Dev Ind Pharm, 2010, 143:154-160
12. Juan Lu,
Qingfei Liu, Xinge Zhao, Rong Gao, Wenjuan Cong, Yiming Wang, Guoan Luo. Simultaneous RP-LC Determination of the Prodrug Scu-PEG and its Metabolite Scutellarin in Rat Plasma.
Chromatographia, 2010,
71(5-6), 511-515
13.
Qingfei Liu, Yun Shi, Yong Wang, Juan Lu, Wenjuan Cong, Guoan Luo, Yiming Wang. Metabolism profile of scutellarin in rat urine following oral administration by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry.
Talanta, 2009, 80: 84-91
14．
Qingfei Liu，Yun Shi, Yuzhen Zhang, Zhongmin Song, Qiang Su, Yu Zhang, Guoan Luo. A Simple and Rapid Method for Determination of Pennogenin Diglycoside in Rat Plasma by High Performance Liquid Chromatography Mass Spectrometry: Application to the Pharmacokinetics of Gongxuening Capsules.
J Chromatogr Sci, 2009, 47 (8): 728-732
15.
Qingfei Liu, Xue Li, Qiang Su，Guoan Luo, Yiming Wang, Weiping Liu. Investigation on pharmacokinetics, tissue distribution and excretion of a novel anticancer platinum compound by inductively coupled plasma mass spectrometry after intravenous administration to rats.
Arch Pharm Resh, 2009, 32 (11): 1621-1628
16. Wenjuan Cong,
Qingfei Liu, Yiming Wang, Guoan Luo. Investigation on the interactions between pirarubicin and phospholipids.
Biophs Chem, 2009, 143: 154-160
17. Su Qiang,
Liu Qingfei, Wang Yong, Bi Kaishun, Luo Guoan. Rapid and sensitive assay on the main components in Shuang-Huang-Lian preparations by UPLC-TOF-MS.
Chem Res Chin Univ, 2009, 25(1): 122-124
18. Xueyan Duan,
Qingfei Liu, Yu Zhang, Kaishun Bi, Xi Chen, Yiming Wang, Guoan Luo. Development of Monolithic Osmotic Pump Tablet System for isosorbide-5mononitrate Delivery and Evaluation of It In Vitro and In Vivo.
Drug Dev Ind Pharm, 2009, 35(4): 499-507
Email: liuqf@tsinghua.edu.cn
