讲座主题：Neural circuits basis of temporal lobe epilepsy 
时间：9月13日10:00-12:00
地点：医学科学楼B323
主持：陈立功 研究员
 
个人简介：
陈忠，浙江大学，教授，博士生导师，浙江大学医药学部副主任，教育部长江学者特聘教授，国家杰出青年科学基金获得者，国家政府特殊津贴获得者，浙江大学求是特聘教授，国家自然科学基金委创新研究群体和教育部创新团队的核心成员， 浙江大学癫痫中心主任。

陈忠博士1992年毕业于上海医科大学药学本科，1999年在日本冈山大学获得博士学位。现为中国药理学学会常务理事，中国药理学会神经精神药理学专业委员会副主任委员，浙江省药理学会理事长。《Neurosci Bull》和《浙江大学学报》（医学版）副主编，《Exp Neurol》《CNS Neurosci Ther》《Sci Rep》《Acta Pharmacol Sin》以及《药学学报》《中国药理学通报》编委。

陈忠教授课题组的主要研究方向为脑缺血和癫痫的发病机制及药物治疗靶点的研究， 在Neuron，Nature Commun，Nature Neurosci，Angew Chem Int Edit，Autophagy等期刊发表SCI学术论文180余篇, 获省科技进步奖一等奖，省自然科学奖一等奖和教育部自然科学一等奖各一项。

Abstract：
Temporal lobe epilepsy (TLE) is a common type of epilepsy and not well controlled by current treatments, but the underlying cellular/circuit mechanisms remain unclear. The early series of our studies have proved the success of low-frequency stimulation treatment for epilepsy, which was mainly depending on the stimulation target, the stimulation frequency and stimulation time (the therapeutic-window phenomenon). Now, by using optogenetics, multiple-channel EEG analysis, imaging, electrophysiological and molecular techniques, we are continued to investigate the circuit mechanism of therapeutic deep brain stimulation, and found that entorhinal principal neurons mediate antiepileptic “glutamatergic-GABAergic” neuronal circuit for brain stimulation treatments of epilepsy. Meanwhile, we are currently focusing on the interplay of inhibitory and excitatory network in subicular microcircuits especially that related to the generation of generalized seizures (GS) in TLE, and we found that depolarized GABAergic signaling in subicular microcircuit mediates GS in TLE. This may be of therapeutic interest in understanding the pathological neuronal circuitry and further the development of novel therapeutic approaches.