“十一五”国家科技计划执行突出贡献奖（2011年）
国务院政府津贴（2011年）
深圳市政府津贴（2010年）
广东省科学技术奖三等奖（2008年，第一完成人）
深圳市科技创新奖（2008年，第一完成人）
深圳市人才“双百计划”（2008年）
教育部“新世纪优秀人才”支持计划（2007年）
广东省劳动模范(2006年)
代表性论文
1. Zhang, W.; Zhang, B.; Zhang, W.; Yang, T.; Wang, N.; Gao, C.; Tan, C.; Liu, H.;
Jiang, Y*., Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors.
Eur. J. Med. Chem.
2016,
116, 59-70.
2. Wang, Y.; Gao, D.; Chu, B.; Gao, C.; Cao, D.; Liu, H.;
Jiang, Y*., Exposure of CCRF-CEM cells to acridone derivative 8a triggers tumor death via multiple mechanisms.
Proteomics
2016,
16 (7), 1177-1190.
3. Chen, Y.; Gao, D.; Liu, H.; Lin, S.;
Jiang, Y*., Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening.
Anal. Chim. Acta
2015,
898, 85-92.
4. Mao, Y.; Liu, M.; Tram, K.; Gu, J.; Salena, B. J.;
Jiang, Y*..; Li, Y., Optimal DNA Templates for Rolling Circle Amplification Revealed by In Vitro Selection.
Chemistry-a European Journal
2015,
21 (22), 8069-8074.
5. Tao, L.; Zhu, F.; Qin, C.; Zhang, C.; Chen, S.; Zhang, P.; Zhang, C.; Tan, C.; Gao, C.; Chen, Z.;
Jiang, Y*.; Chen, Y. Z., Clustered Distribution of Natural Product Leads of Drugs in the Chemical Space as Influenced by the Privileged Target-Sites.
Scientific Reports
2015,
5.
6. Zhang, B.; Chen, K.; Wang, N.; Gao, C.; Sun, Q.; Li, L.; Chen, Y.; Tan, C.; Liu, H.;
Jiang, Y*., Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents.
Eur. J. Med. Chem.
2015,
93, 214-226.
7. Mao, Y.; Chen, Y.; Li, S.; Lin, S.;
Jiang, Y*.., A Graphene-Based Biosensing Platform Based on Regulated Release of an Aptameric DNA Biosensor.
Sensors (Basel, Switzerland)
2015,
15 (11), 28244-56.
8. Gao, C.; Li, B.; Zhang, B.; Sun, Q.; Li, L.; Li, X.; Chen, C.; Tan, C.; Liu, H.;
Jiang, Y*., Synthesis and biological evaluation of benzimidazole acridine derivatives as potential DNA-binding and apoptosis-inducing agents.
Bioorg. Med. Chem.
2015,
23 (8), 1800-1807.
9. Li, X.; Gao, C.; Yang, T.; Zhang, B.; Tan, C.; Liu, H.;
Jiang, Y*., A POCl3-mediated synthesis of substituted fused azoacridones derivatives.
Rsc Advances
2015,
5 (36), 28670-28678.
10. He, S.; Qu, L.; Shen, Z.; Tan, Y.; Zeng, M.; Liu, F.;
Jiang, Y*.; Li, Y., Highly Specific Recognition of Breast Tumors by an RNA-Cleaving Fluorogenic DNAzyme Probe.
Analytical Chemistry
2015,
87 (1), 569-577.
11. Chu, B.; Liu, F.; Li, L.; Ding, C.; Chen, K.; Sun, Q.; Shen, Z.; Tan, Y.; Tan, C.;
Jiang, Y*., A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells.
Cell death & disease
2015,
6, e1686.
12. Chen, K.; Chu, B.-z.; Liu, F.; Li, B.; Gao, C.-m.; Li, L.-l.; Sun, Q.-s.; Shen, Z.-f.;
Jiang, Y*., New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway.
Acta Pharmacologica Sinica
2015,
36 (9), 1074-1084.
13. Gao, F.; Liu, F.; Zheng, J.; Zeng, M.;
Jiang, Y*., A Catalytic DNA Probe with Stem-loop Motif for Human T47D Breast Cancer Cells.
Analytical Sciences
2015,
31 (8), 815-822.
14. Liu, H.; Li, X.; Liu, F.; Tan, Y.;
Jiang, Y*., A simple and novel amide ligand based on quinoline derivative used for palladium-catalyzed Suzuki coupling reaction.
Journal Of Organometallic Chemistry
2015,
794, 27-32.
15. Tao, L.; Zhu, F.; Xu, F.; Chen, Z.;
Jiang, Y*.; Chen, Y. Z., Co-targeting cancer drug escape pathways confers clinical advantage for multi-target anticancer drugs.
Pharmacological Research
2015,
102, 123-131.
16. Qin, C.; Tao, L.; Phang, Y. H.; Zhang, C.; Chen, S. Y.; Zhang, P.; Tan, Y.;
Jiang, Y*.; Chen, Y. Z., The Assessment of the Readiness of Molecular Biomarker-Based Mobile Health Technologies for Healthcare Applications.
Scientific Reports
2015,
5.
17. Tao, L.; Zhu, F.; Qin, C.; Zhang, C.; Xu, F.; Tan, C. Y.;
Jiang, Y*.; Chen, Y. Z., Nature's contribution to today's pharmacopeia.
Nature biotechnology
2014,
32 (10), 979-80.
18. Zhang, B.; Li, X.; Li, B.; Gao, C.;
Jiang, Y*., Acridine and its derivatives: a patent review (2009-2013).
Expert Opinion on Therapeutic Patents
2014,
24 (6), 647-664.
19. Xin, T.; Zhang, C.; Tan, C.;
Jiang, Y*., Biological Evaluation and Structure Modification of (S)-3-Aminopyrrolidine Derivatives.
Chemical Research in Chinese Universities
2014,
30 (1), 91-97.
20. Wu, Q.; Gao, D.; Wei, J.; Jin, F.; Xie, W.;
Jiang, Y*.; Liu, H., Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening.
Chemical Communications
2014,
50 (21), 2762-2764.
21. Li, B.; Gao, C.-M.; Sun, Q.-S.; Li, L.-L.; Tan, C.-Y.; Liu, H.-X.;
Jiang, Y*., Novel synthetic acridine-based derivatives as topoisomerase I inhibitors.
Chin. Chem. Lett.
2014,
25 (7), 1021-1024.
22. Gao, D.; Jin, F.; Liu, H.; Wang, Y.;
Jiang, Y*., Metabonomic study on the antitumor effect of flavonoid derivative 3d in HepG2 cells and its action mechanism.
Talanta
2014,
118, 382-388.
23. Chen, X.; Gao, D.; Liu, F.; Gao, X.; Wang, S.; Zhao, Y.; Liu, H.;
Jiang, Y*., A novel quantification method for analysis of twenty natural amino acids in human serum based on N-phosphorylation labeling using reversed-phase liquid chromatography-tandem mass spectrometry.
Anal. Chim. Acta
2014,
836, 61-71.
24. Ding, C.; Zhang, C. L.; Zhang, M. L.; Chen, Y. Z.; Tan, C. Y.; Tan, Y.;
Jiang, Y*., Multitarget inhibitors derived from crosstalk mechanism involving VEGFR2.
Future Med Chem
2014,
6 (16), 1771-1789.
25. Qu, L.; Ali, M. M.; Aguirre, S. D.; Liu, H.;
Jiang, Y*.; Li, Y., Examination of Bacterial Inhibition Using a Catalytic DNA.
PLoS One
2014,
9 (12).
26. Chen, Z.; Liu, F.; Zhang, N.; Cao, D.; Liu, M.; Tan, Y.;
Jiang, Y*., p38 beta, A Novel Regulatory Target of Pokemon in Hepatic Cells.
Int. J. Mol. Sci.
2013,
14 (7), 13511-13524.
27. Jin, F.; Gao, D.; Wu, Q.; Liu, F.; Chen, Y.; Tan, C.;
Jiang, Y*., Exploration of N-(2-aminoethyl)piperidine-4-carboxamide as a potential scaffold for development of VEGFR-2, ERK-2 and Abl-1 multikinase inhibitor.
Bioorg. Med. Chem.
2013,
21 (18), 5694-5706.
28. Jin, F.; Gao, D.; Zhang, C.; Liu, F.; Chu, B.; Chen, Y.; Chen, Y. Z.; Tan, C.;
Jiang, Y*., Exploration of 1-(3-chloro-4-(4-oxo-4H-chromen-2-yl)phenyl)-3-phenylurea derivatives as selective dual inhibitors of Raf1 and JNK1 kinases for anti-tumor treatment.
Bioorg. Med. Chem.
2013,
21 (3), 824-831.
29. Jin, X. L.; Sun, Q. S.; Liu, F.; Yang, H. W.; Liu, M.; Liu, H. X.; Xu, W.;
Jiang, Y*., microRNA 21‐mediated suppression of Sprouty1 by Pokemon affects liver cancer cell growth and proliferation.
Journal of Cellular Biochemistry
2013,
114, 1625-1633.
30. Lang, X.; Li, L.; Chen, Y.; Sun, Q.; Wu, Q.; Liu, F.; Tan, C.; Liu, H.; Gao, C.;
Jiang, Y*., Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents.
Bioorg. Med. Chem.
2013,
21 (14), 4170-4177.
31. Lang, X.-L.; Sun, Q.-S.; Chen, Y.-Z.; Li, L.-L.; Tan, C.-Y.; Liu, H.-X.; Gao, C.-M.;
Jiang, Y*., Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase I inhibitor.
Chin. Chem. Lett.
2013,
24 (8), 677-680.
32. Liu, R.; Tan, Y.; Zhang, C.; Wu, J.; Mei, L.;
Jiang, Y*.; Tan, C., A real-time fluorescence turn-on assay for trypsin based on a conjugated polyelectrolyte.
Journal of Materials Chemistry B
2013,
1 (10), 1402-1405.
33. Wu, J.; Tan, Y.; Xie, Y.; Wu, Y.; Zhao, R.;
Jiang, Y*.; Tan, C., Diazobenzene-containing conjugated polymers as dark quenchers.
Chemical Communications
2013,
49 (97), 11379-11381.
34. Zhang, N.-N.; Sun, Q.-S.; Chen, Z.; Liu, F.;
Jiang, Y*., Homeostatic regulatory role of Pokemon in NF-kappa B signaling: stimulating both p65 and I kappa B alpha expression in human hepatocellular carcinoma cells.
Molecular and Cellular Biochemistry
2013,
372 (1-2), 57-64.
35. Gao, D.; Liu, H.; Lin, J.-M.; Wang, Y.;
Jiang, Y*., Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device.
Lab on a Chip
2013,
13 (5), 978-985.
36. Wang, Y.; Gao, D.; Chen, Z.; Li, S.; Gao, C.; Cao, D.; Liu, F.; Liu, H.;
Jiang, Y*., Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents.
Plos One
2013,
8 (5), e63572.
37. Gao, C. M.; Li, S. F.; Lang, X. L.; Liu, H. X.; Liu, F.; Tan, C. Y.;
Jiang, Y*., Synthesis and evaluation of 10-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as selective telomeric G-quadruplex DNA ligands.
Tetrahedron
2012,
68 (38), 7920-7925.
38. Gao, X.; Wu, H.; Lee, K.-C.; Liu, H.; Zhao, Y.; Cai, Z.;
Jiang, Y*., Stable Isotope N-Phosphorylation Labeling for Peptide de Novo Sequencing and Protein Quantification Based on Organic Phosphorus Chemistry.
Analytical chemistry
2012,
84 (23), 10236-10244.
39. Han, B. C.; Ma, X. H.; Zhao, R. Y.; Zhang, J. X.; Wei, X. N.; Liu, X. H.; Liu, X.; Zhang, C. L.; Tan, C. Y.;
Jiang, Y*.; Chen, Y. Z., Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries.
Chem Cent J
2012,
6.
40. Jin, F.; Zhang, N.; Tan, C.; Gao, D.; Zhang, C.; Liu, F.; Chen, Z.; Gao, C.; Liu, H.; Li, S.;
Jiang, Y*., 2'-Chloro-4'-aminoflavone Derivatives Selectively Targeting Hepatocarcinoma Cells: Convenient Synthetic Process, G2/M Cell Cycle Arrest and Apoptosis Triggers.
Archiv Der Pharmazie
2012,
345 (7), 525-534.
41. Jin, Y. B.; Luan, X. D.; Liu, H. X.; Gao, C. M.; Li, S. F.; Cao, D. L.; Li, X. Y.; Cai, Z. W.;
Jiang, Y*., Pharmacokinetics and metabolite identification of a novel VEGFR-2 and Src dual inhibitor 6-chloro-2-methoxy-N-(2-methoxybenzyl) acridin-9-amine in rats by liquid chromatography tandem mass spectrometry.
Talanta
2012,
89, 70-76.
42. Zhu, F.; Ma, X. H.; Qin, C.; Tao, L.; Liu, X.; Shi, Z.; Zhang, C. L.; Tan, C. Y.; Chen, Y. Z.;
Jiang, Y*., Drug Discovery Prospect from Untapped Species: Indications from Approved Natural Product Drugs.
Plos One
2012,
7 (7).
43. Zhao, R.; Xie, Y. H.; Tan, Y.; Tan, C. Y.;
Jiang, Y*., Binding of a bcl-2 Family Inhibitor to Bovine Serum Albumin: Fluorescence Quenching and Molecular Docking Study.
Protein and Peptide Letters
2012,
19 (9), 949-954.
44. Zhang, X.; Tan, Y.; Zhao, R.; Chu, B.; Tan, C.;
Jiang, Y*., Site-directed Mutagenesis Study of the Ile140 in Conserved Hydrophobic Core of Bcl-x(L).
Protein and Peptide Letters
2012,
19 (9), 991-996.
45. Zhang, J. X.; Han, B. C.; Wei, X. N.; Tan, C. Y.; Chen, Y. Z.;
Jiang, Y*., A Two-Step Target Binding and Selectivity Support Vector Machines Approach for Virtual Screening of Dopamine Receptor Subtype-Selective Ligands.
Plos One
2012,
7 (6).
46. Zhang, J.; Jia, J.; Zhu, F.; Ma, X.; Han, B.; Wei, X.; Tan, C.;
Jiang, Y*.; Chen, Y., Analysis of bypass signaling in EGFR pathway and profiling of bypass genes for predicting response to anticancer EGFR tyrosine kinase inhibitors.
Molecular bioSystems
2012,
8 (10), 2645-56.
47. Zhang, C. L.; Tan, C. Y.; Ding, H. W.; Xin, T.;
Jiang, Y*., Selective VEGFR Inhibitors for Anticancer Therapeutics in Clinical Use and Clinical Trials.
Current Pharmaceutical Design
2012,
18 (20), 2921-2935.
48. Yang, X. F.; Zu, X. Y.; Tang, J.; Xiong, W.; Zhang, Y.; Liu, F.;
Jiang, Y*., Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation.
Molecular Medicine Reports
2012,
5 (6), 1475-1480.
49. Xie, Y. H.; Zhao, R.; Tan, Y.; Zhang, X.; Liu, F.;
Jiang, Y*.; Tan, C. Y., Conjugated Polymer-Based Real-Time Fluorescence Caspase Assays.
ACS Applied Materials & Interfaces
2012,
4 (1), 405-410.
50. Xie, Y. H.; Tan, Y.; Liu, R. X.; Zhao, R.; Tan, C. Y.;
Jiang, Y*., Continuous and Sensitive Acid Phosphatase Assay Based on a Conjugated Polyelectrolyte.
ACS Applied Materials & Interfaces
2012,
4 (8), 3784-3787.
51. Tian, J.;
Jiang, Y*., Insulin upregulates the expression of zinc finger and BTB domain-containing 7A in HepG2 cells.
Molecular Medicine Reports
2012,
6 (6), 1379-1384.
52. Tan, Y.; Zhang, X.; Xie, Y. H.; Zhao, R.; Tan, C. Y.;
Jiang, Y*., Label-free fluorescent assays based on aptamer-target recognition.
Analyst
2012,
137 (10), 2309-2312.
53. Liu, K.; Liu, F.; Zhang, N. N.; Liu, S. Y.;
Jiang, Y*., Pokemon Silencing Leads to Bim-Mediated Anoikis of Human Hepatoma Cell QGY7703.
Int. J. Mol. Sci.
2012,
13 (5), 5818-5831.
54. Lin, J. S.; Liu, F.;
Jiang, Y*., Antisense Technologies Targeting Fatty Acid Synthetic Enzymes.
Recent Patents on Anti-Cancer
Drug Discovery
2012,
7 (2), 198-206.
55. Lin, J.; Jin, X.; Bu, Y.; Cao, D.; Zhang, N.; Li, S.; Sun, Q.; Tan, C.; Gao, C.;
Jiang, Y*., Efficient synthesis of RITA and its analogues: derivation of analogues with improved antiproliferative activity via modulation of p53/miR-34a pathway.
Organic & Biomolecular Chemistry
2012,
10 (48), 9734-9746.
56. Lang, X. L.; Luan, X. D.; Gao, C. M.;
Jiang, Y*., Recent Progress of Acridine Derivatives with Antitumor Activity.
Progress in Chemistry
2012,
24 (8), 1497-1505.
57. Zu, X.; Ma, J.; Liu, H.; Liu, F.; Tan, C.; Yu, L.; Wang, J.; Xie, Z.; Cao, D.;
Jiang, Y*., Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression.
Breast Cancer Res.
2011,
13, R26.
58. Zhu, F.; Qin, C.; Tao, L.; Liu, X.; Shi, Z.; Ma, X.; Jia, J.; Tan, Y.; Cui, C.; Lin, J.; Tan, C.;
Jiang, Y*.; Chen, Y., Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting.
Proc. Natl. Acad. Sci. U. S. A.
2011,
108 (31), 12943-12948, S12943/1-S12943/139.
59. Zhao, R.; Tan, C.; Xie, Y.; Gao, C.; Liu, H.;
Jiang, Y*., One step synthesis of azo compounds from nitroaromatics and anilines.
Tetrahedron Lett.
2011,
52 (29), 3805-3809.
60. Zhang, Y.; Zu, X. Y.; Luo, W. S.; Tang, S. S.;
Jiang, Y*., siRNA Induced CyclinB1 Knockdown Sensitizes HepG2 Cells to Daunorubicin.
Prog. Biochem. Biophys.
2011,
38 (6), 551-557.
61. Zhang, D.; Liu, H.; Zhang, S.; Chen, X.; Li, S.; Zhang, C.; Hu, X.; Bi, K.; Chen, X.;
Jiang, Y*., An effective method for de novo peptide sequencing based on phosphorylation strategy and mass spectrometry.
Talanta
2011,
84 (3), 614-622.
62. Zhang, C.; Zhai, X.; Wan, F.; Gong, P.;
Jiang, Y*., 2-Chloro-1- 4-(2-fluorobenzyl)piperazin-1-yl ethanone.
Acta Crystallographica Section E-Structure Reports Online
2011,
67, O708-U2523.
63. Zhang, C.; Tan, C.; Zu, X.; Zhai, X.; Liu, F.; Chu, B.; Ma, X.; Chen, Y.; Gong, P.;
Jiang, Y*., Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors.
Eur. J. Med. Chem.
2011,
46 (4), 1404-1414.
64. Luan, X.; Gao, C.; Zhang, N.; Chen, Y.; Sun, Q.; Tan, C.; Liu, H.; Jin, Y.;
Jiang, Y*., Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors.
Bioorg. Med. Chem.
2011,
19 (11), 3312-3319.
65. Luan, X.; Gao, C.; Sun, Q.; Tan, C.; Liu, H.; Jin, Y.;
Jiang, Y*., Novel synthetic azaacridine analogues as topoisomerase 1 inhibitors.
Chem. Lett.
2011,
40 (7), 728-729.
66. Li, Y.; Tan, C.; Gao, C.; Zhang, C.; Luan, X.; Chen, X.; Liu, H.; Chen, Y.;
Jiang, Y*., Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors.
Bioorg. Med. Chem.
2011,
19 (15), 4529-4535.
67. Li, S.; Liu, H.; Jin, Y.; Lin, S.; Cai, Z.;
Jiang, Y*., Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice.
J. Chromatogr., B: Anal. Technol. Biomed. Life Sci.
2011,
879 (24), 2369-2375.
68. Hu, X.; Gao, C.; Tan, C.; Zhang, C.; Zhang, H.; Li, S.; Liu, H.;
Jiang, Y*., Design and Synthesis of N-phosphoryl Peptide Modified Podophyllotoxin Derivatives as Potent Anticancer Agents.
Protein and Peptide Letters
2011,
18 (12), 1258-1264.
69. Chen, X. W.; Liu, H. X.; Jin, Y. B.; Li, S. F.; Bi, X.; Chung, S.; Zhang, S. S.;
Jiang, Y*., Separation, identification and quantification of tetrodotoxin and its analogs by LC-MS without calibration of individual analogs.
Toxicon
2011,
57 (6), 938-943.
