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代表性论文

1.      Huang, J.; Yuan, Y.; Zhao, N.; Pu, D.; Tang, Q.; Zhang, S.; Luo, S.; Yang, X.; Wang, N.; Xiao, Y.; Zhang, T.; Liu. Z.; Sakata-Kato, Y.; Hirata, K.; *Jiang, X.; *Kato, N.; *Yan, N.; *Yin, H. “Orthosteric-Allosteric Dual Inhibitors of PfHT1 as Selective Anti-Malarial Agents”, Proc. Natl. Acad. Sci. U. S. A. 2021, 118, e2017749118.
2.      Jiang, X.; Yuan, Y.; Huang, J.; Zhang, S.; Luo, S.; Wang, N.; Pu, D.; Zhao, N.; Tang, Q.; Hirata, K.; Yang, X.; Jiao, Y.; Sakata-Kato, Y.; Wu, J.; Yan, C.; Kato, N.; *Yin, H.; *Yan, N. “Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum”, Cell 2020, 183, 258-268.
3.      Xu, Q.; Dai, C.; Kong, J.; Chen, H.; Feng, J.; Zhang, Y.; *Yin, H. “Immune Profiling Before Treatment is Predictive of TLR9-Induced Antitumor Efficacy”, Biomaterials 2020, 263, 120379.
4.      Xiao, Y.; Driedonks, T.; Witwer, K.; Wang, Q.; *Yin, H. “How Does an RNA Selfie Work? EV-Associated RNA in Innate Immunity as Self or Danger”, J. Extracell. Vesicles 2020, 9, e1793515.
5.      Wang, Y.; Zhang, S.; Li, H.; Wang, H.; Zhang, T.; Hutchinson, M.; *Yin, H.; *Wang, X. “Small Molecule Modulators of Toll-Like Receptors”, Acc. Chem. Res. 2020, 53, 1046-1055 (cover article).
6.      Jiang, S.; Tanji, H.; Yin, K.; Zhang, S.; Sakaniwa, K.; Huang, J.; Yang, Y.; Li, J.; Ohto, U.; Shimizu, T.; *Yin, H. “Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface”, J. Med. Chem. 2020, 63, 4117-4132
7.      Gao, M.; Huang, J.; Jiang, X.; Yuan, Y.; Luo, S.; Wang, N.; Pang, H.; Deng, D.; Yao, C.; Lin, Z.; Pu, D.; Liu, Z.; Hu, Z.; *Yin, H. “Regulation of Aerobic Glycolysis to Decelerate Tumor Proliferation by Small Molecule Inhibitors Targeting Glucose Transporters”, Protein Cell 2020, 11, 446-451.
8.      Zhang, Y.; Jin, X.; Liang, J.; Guo, Y.; Sun, G.; Zeng, X.; *Yin, H. “Extracellular Vesicles Derived from ODN-Stimulated Macrophages Promote Their Cellular Uptake by the Transfer and Activation of Cdc42”, Sci. Adv. 2019, 5, eaav1564.
9.      Padilla-Salinas, R.; Anderson, R.; Sakaniwa, K.; Zhang, S.; Nordeen, P.; Lu, C.; Shimizu, S.; *Yin, H. “Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptor 7 and 8”, J. Med. Chem. 2019, 62, 10221-10244.
10.   Tamura, R.; Balabanova, A.; Frakes, S. A.; Bargmann, A.; Koch, T. H.; *Yin, H. “Photoactivatable Prodrug of Doxazolidine Targeting Exosomes”, J. Med. Chem. 2019, 62, 1959-1970.
11.   Hu, Z.; Tanji, H.; Jiang, S.; Zhang, S.; Koo, K.; Chan, J.; Sakaniwa, K.; Ohto, U.; Candia, A.; Shimizu, T.; *Yin, H. “Small Molecule TLR8 Antagonists via Structure-Based Rational Design”, Cell Chem. Biol. 2018, 25, 1286-1291 (cover article).
12.   Bhattacharyya, S.; Wang, W.; Qin, W.; Cheng, K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.; Tamaki, Z.; *Yin, H.; *Varga, J. “TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skin and Lung”, JCI Insight 2018, 3, e98850 (featured in “News & Views” Nat. Rev. Rheumatol. 2018, 14, 564-566).
13.   Zhang, L.; Shi, L.; Soars, S. M.; Kamps, J.; *Yin, H. “Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Anti-Inflammatory and Anti-Cancer Properties”, J. Med. Chem. 2018, 61, 5881-5899.
14.   Zhang, S.; Hu, Z.; Tanji, H.; Jiang, S.; Das, N.; Li, J.; Sakaniwa, K.; Jin, J.; Bian, Y.; Ohto, U.; Shimizu, T.; *Yin, H. “Small Molecule Inhibition of TLR8 through Stabilization of Its Resting State”, Nat. Chem. Biol. 2018, 14, 58-64 (cover article; featured as C&EN “Latest News”).
15.   Zhang, L.; Dewan, V.; *Yin, H. “Discovery of Small Molecules as Multi-TLR Agonists with Proinflammatory and Anticancer Activities”, J. Med. Chem. 2017, 60, 5029-5044.
16.   Smith, C. E.; Soti, S.; Jones, T. A.; Nakagawa, A.; Xue, D.; *Yin, H. “NSAIDs are Caspase Inhibitors”, Cell Chem. Biol. 2017, 24, 281-292 (featured in “Concentrates” C&EN 2017, 95(10), 10; NIH Research Matters; The Sun; Daily Mail; WebMD).
17.   Das, N.; Dewan, V.; Grace, P. M.; Rosenfeld-Gunn, R. J.; Tamura, R.; Tzarum, N.; Watkins, L. R.; Wilson, I. A.; *Yin, H. “HMGB-1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia”, Cell Rep. 2016, 17, 1128-1140.
18.   *Yin, H.; Flynn, A. D. “Drugging Membrane Protein Interactions”, Annu. Rev. Biomed. Eng. 2016, 18, 51-76.
19.   Daniele, S. G.; Beraud, D.; Davenport, C.; Cheng, K.; *Yin, H.; *Maguire-Zeiss, K. A. “Activation of MyD88-Dependent TLR1/2 Signaling by Misfolded α-Synuclein, a Protein Linked to Neurodegenerative Disorders”, Sci. Signal. 2015, 8, ra45 (highlighted in “This Week in Science” Science 2015, 348, 769; Podcast: Maguire-Zeiss, K. A.; Daniele, S. G.; Yin, H.; VanHook, A. M.; Sci. Signal. 2015, 8, pc12).      
20.   Cheng, K.; Gao, M.; Godfroy III, J. I.; Brown, P. N.; Kastelowitz, N.; *Yin, H. “Specific Activation of the TLR1-TLR2 Heterodimer by Small-molecule Agonists”, Sci. Adv. 2015, 1, e1400139 (featured in “Science & Technology” C&EN 2015, 93(15), 39-40; The Pharmaceutical Journal News).
Smith, C. E.; Wang, X. H.; *Yin, H. “Caspases Come Together Over LPS”, Trends Immunol. 2015, 36, 59-61.