（1）新型载药系统的研究开发。通过缓控释制剂、纳米药物制剂与环境响应型制剂的开发，提高药物的生物利用度与递送效率；采用固体分散、静电纺丝、微流控、3D打印等技术结合原位凝胶等新材料，发展新型载药系统。
（2）中药物质基础与作用机理研究。参与首个网络药理学国际标准的制订；基于成分分析、组学研究及药效评价，结合网络药理学，探讨中药药性与炮制机理、中医证候机制以及中药复方物质基础与作用机理，开发新型中药制剂。
（3）药物代谢动力学研究。对铂类抗癌药物、中药活性成分及药物新制剂进行药物代谢动力学研究，基于LC/MS检测、计算方法开发、化学合成，发现药物的体内代谢产物，明确药物的ADME特征。
1. Guoan Luo, Yiming Wang, Qionglin Liang, Qingfei Liu. System biology for TCM, John Wiley Press, 2012；
2. 罗国安，王义明，梁琼麟， 刘清飞。中医药系统生物学。科学出版社，2011；
3. 药物新剂型。编委，化学工业出版社，2003。
1. Jing Jiang, Fuguo Han, Kaixuan Cai, Qiushuo Shen, Cuiping Yang， Anli Gao, Juan Yu, Xuemei Fan, Yanli Hao, Zhao Wang, Weiping Liu*, Yun Shi*, Qingfei Liu*. Synthesis and biological evaluation of cholic acid-conjugated oxaliplatin as a new prodrug for liver cancer. Journal of Inorganic Biochemistry, 2023, 243, 112200.
2. Yifei Liu, Xuemei Fan, Huanhuan Pang, Saiya Liu, Bohong Wang, Chunmei Wang, Qingya Yan, Wenping Song, Zeping Hu*, Qingfei Liu*, Yun Shi*. Metabolomics reveals a panel of biomarkers for early human embryonic development arrest. Journal of Proteome Research, 2023, 22, 1280-1286.
3. Fei Yan, Qi Zhao, Huanpeng Gao, Xiaomei Wang, Ke Xu, Yishu Wang, Fuguo Han, Qingfei Liu*, Yun Shi*. Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation. Bioscience Report, 2021, 41, BSR20203955.
4. Xianzhi Su, Xiaomei Wang, Yifei Liu, Wenjuan Kong, Fei Yan, Fuguo Han, Qingfei Liu*, Yun Shi*. Effect of Jiajian Guishen Formula on the senescence-associated heterochromatic foci in mouse ovaria after induction of premature ovarian aging by the endocrine-disrupting agent 4-vinylcyclohexene diepoxide. Journal of Ethnopharmacology, 2021, 269, 113720.
5 Yingxue Li, Fanzhuo Meng, Zhijian Chen, Fuguo Han, Donglin He, Anli Gao, Jing Jiang, Weiping Liu*, Qingfei Liu*. Pharmacokinetics and tissue distribution of a novel anticancer platinum compound LLC-1903 to rats. Xenobiotica, 2020, 50(8), 980-987.
6. Huang Qing; Li Liyuan; Chen Huiling; Liu Qingfei*; Wang Zhao*. GPP (Composition of Ganoderma Lucidum Poly-saccharides and Polyporus Umbellatus Poly-saccharides) Enhances Innate Immune Function in Mice. Nutrients, 2019, 11, 1480.
7. Chen, Huiling; Huang, Qing; Zhang, Shunjia; Hu, Kaiqiang; Xiong, Wenxiang; Xiao, Lingyun; Cong, Renhuai; Liu, Qingfei*; Wang, Zhao*. The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice. Nutrients, 2019, 11(4), 859.
8. Huan-Huan Qiao, Fang Wang, Rong-Gang Xu, Jin Sun, Ruibao Zhu, Decai Mao, Xingjie Ren, Xia Wang, Yu Jia, Ping Peng, Da Shen, Lu-Ping Liu, Zhijie Chang, Guirong Wang, Shao Li, Jun-Yuan Ji, Qingfei Liu, Jian-Quan Ni*. An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila. Nature Communications, 2018, 9, 4160.
9. Yu Jia, Rong-Gang Xua, Xingjie Ren, Ben Ewen-Campenc, Rajendhran Rajakumar, Jonathan Zirin, Donghui Yang-Zhou, Ruibao Zhu, Fang Wang, Decai Mao, Ping Peng, Huan-Huan Qiao, Xia Wang, Lu-Ping Liu, Bowen Xu, Jun-Yuan Ji, Qingfei Liu, Jin Sun, Norbert Perrimon, and Jian-Quan Ni*. Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM. PNAS, 2018, 115(18), 4719-4724.
10. Ren Xingjie; Holsteens Kristof; Li Haiyi; Sun Jin; Zhang Yifan; Liu Lu-Ping; Liu Qingfei*; Ni Jianquan*. Genome editing in Drosophila melanogaster: from basic genome engineering to the multipurpose CRISPR-Cas9 system. Science China-life Sciences, 2017, 60(5), 476-489.
11. Donglin He, Shuhui Yin, Fuguo Han, Jingjie Zhu, Yun Shi, Zhiyuan Tong, Qingfei Liu*. Pharmacokinetics and Tissue Distribution of Two Novel Isomerism Anticancer Platinum Compounds. Drug development and industrial pharmacy, 2016, 42(11), 1792-1799.
12. Zhengguang Li, Rui Zhang, Xiuping Wang, Xiaofei Hu, Yuguo Chen*, Qingfei Liu*. Simultaneous determination of seven ginsenosides in rat plasma by high performance liquid chromatography coupled to time-of-flight mass spectrometry: Application to pharmacokinetics of Shenfu injection. Biomedical Chromatography, 2015, 29(2), 167-175.
13. Qingfei Liu, Yun Shi, Tuo Guo, Yong Wang, Wenjuan Cong, Jingjie Zhu. Metabolite discovery of helicidum in rat urine with XCMS based on the data of ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. Journal of Chromatography B, 2012, 907, 146-153.
14．Qingfei Liu, Walter Luyten, Klaartje Pellens, Yiming Wang, Wei Wang, Karin Thevissen, Qionglin Liang, Bruno P.A. Cammue, Liliane Schoofs, Guoan Luo. Screening for Antifungal Plants from Chinese Traditional and Folk Medicines, Journal of Ethnopharmacology, 2012, 143(3), 772-778.
15．Jun Shi, Qingfei Liu*, Yiming Wang, Guoan Luo*. Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats. Pharmacology, Biochemistry and Behavior, 2010, 96, 449-453.
16. Wenjuan Cong, Qingfei Liu*, Xi Chen, Rong Gao, Juan Lu, Yiming Wang, Guoan Luo*. Characterization and Pharmacokinetics of a Novel Pirarubicin Liposome Powder. Drug development and industrial pharmacy, 2010, 143, 154-160.
17. Wenjuan Cong, Qingfei Liu*, Yiming Wang, Guoan Luo*. Investigation on the interactions between pirarubicin and phospholipids. Biophysical Chemistry, 2009, 143, 154-160.
18. Qingfei Liu, Yun Shi, Yong Wang, Juan Lu, Wenjuan Cong, Guoan Luo, Yiming Wang. Metabolism profile of scutellarin in rat urine following oral administration by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. Talanta, 2009, 80, 84-91.
19．Qingfei Liu，Yun Shi, Yuzhen Zhang, Zhongmin Song, Qiang Su, Yu Zhang, Guoan Luo. A Simple and Rapid Method for Determination of Pennogenin Diglycoside in Rat Plasma by High Performance Liquid Chromatography Mass Spectrometry: Application to the Pharmacokinetics of Gongxuening Capsules. Journal of Chromatographic Science, 2009, 47(8), 728-732.
20. Qingfei Liu, Xue Li, Qiang Su，Guoan Luo, Yiming Wang, Weiping Liu. Investigation on pharmacokinetics, tissue distribution and excretion of a novel anticancer platinum compound by inductively coupled plasma mass spectrometry after intravenous administration to rats. Archives of Pharmacal Research, 2009, 32 (11), 1621-1628.
21. Su Qiang, Liu Qing-fei*, Wang Yong, Bi Kai-shun, Luo Guo-an*. Rapid and sensitive assay on the main components in Shuang-Huang-Lian preparations by UPLC-TOF-MS. Chemical Research in Chinese Universities, 2009, 25(1), 122-124.
22. Qingfei Liu, Xiangdong Liu, Guoan Luo, Weiwei Tian, Yiming Wang. Determination of helicidum and its metabolites in dog plasma by LC/UV/MS/MS and its application to pharmacokinetic studies. Journal of Chromatography B, 2006, 832, 185-190.
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