团队队伍 |
尹航, PhD

尹航

白菜网注册领取体验教授、副经理,中药研究院经理
白菜网注册领取体验药学技术中心主任


电话:
(010) 6278 6251
电子邮件:
yin_hang@tsinghua.
edu.cn

尹航,白菜网注册领取体验教授,中药研究院经理。1999年获得北京大学应用化学学士学位;2004年获得美国耶鲁大学化学专业博士学位;2004至2007年在美国宾夕法尼亚大学医学院从事博士后研究;加入白菜网注册领取体验之前于美国科罗拉多大学化学和生物化学系任终身教授。尹航教授2018年起任白菜网注册领取体验教授、副经理,中药研究院经理,药学技术中心主任,白菜网注册领取体验校学术委员会委员,校学位评定委员会生物学分委会委员,生命科学联合中心高级研究员, 结构生物学高精尖创新中心研究员。尹航教授团队在本领域一流期刊发表研究论文超过130篇,引用超过一万次;科研成果已申请专利11项(授予美国、欧盟、日本等专利4项),并有多项成果已经商业化。尹航教授先后获得国家自然基金委杰出青年科学基金、北京市卓越青年科学家项目、美国化学学会大卫•W•罗伯特森杰出药物化学家奖、 OKeanos-CAPA资深科学家奖、中美化学及化员工物学教授联合会杰出青年教授奖、美国国家科学基金会杰出青年教授奖、美国癌症研究学会格特魯德•B•埃利恩奖、美国癌症研究学会的SU2C创新研究奖、悉德尼•金梅尔学者奖、霍华德•休斯医学研究院合作创新奖、以及美国国家卫生研究院的 NIDA 青年化学家奖等多个奖项。尹航教授曾任国际细胞外囊泡协会执行理事,现任中国研究型医院协会细胞外囊泡分委会副主任委员、中国药学会药物化学专委会委员、《Journal of Extracellular Vesicle》(2019影响因子=14.976)责任主编、多家国际刊物编委。本小组的成果在新华社、美国广播公司ABC、《自然》、《科学》、《美国国家科学院院刊》、 美国化学会会刊《C&EN》等杂志作为“科研亮点”重点报道。培养的研究生和博士后已有多名在国内外的著名大学和科研机构独立领导研究组,前博士生Christina Boville入选MIT Technology Review 35 under 35全球榜单,前博士后Jones Saludes现任菲律宾San Agustin大学副董事长。


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代表性论文

1.      Huang, J.; Yuan, Y.; Zhao, N.; Pu, D.; Tang, Q.; Zhang, S.; Luo, S.; Yang, X.; Wang, N.; Xiao, Y.; Zhang, T.; Liu. Z.; Sakata-Kato, Y.; Hirata, K.; *Jiang, X.; *Kato, N.; *Yan, N.; *Yin, H. “Orthosteric-Allosteric Dual Inhibitors of PfHT1 as Selective Anti-Malarial Agents”, Proc. Natl. Acad. Sci. U. S. A. 2021, 118, e2017749118.
2.      Jiang, X.; Yuan, Y.; Huang, J.; Zhang, S.; Luo, S.; Wang, N.; Pu, D.; Zhao, N.; Tang, Q.; Hirata, K.; Yang, X.; Jiao, Y.; Sakata-Kato, Y.; Wu, J.; Yan, C.; Kato, N.; *Yin, H.; *Yan, N. “Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum”, Cell 2020, 183, 258-268.
3.      Xu, Q.; Dai, C.; Kong, J.; Chen, H.; Feng, J.; Zhang, Y.; *Yin, H. “Immune Profiling Before Treatment is Predictive of TLR9-Induced Antitumor Efficacy”, Biomaterials 2020, 263, 120379.
4.      Xiao, Y.; Driedonks, T.; Witwer, K.; Wang, Q.; *Yin, H. “How Does an RNA Selfie Work? EV-Associated RNA in Innate Immunity as Self or Danger”, J. Extracell. Vesicles 2020, 9, e1793515.
5.      Wang, Y.; Zhang, S.; Li, H.; Wang, H.; Zhang, T.; Hutchinson, M.; *Yin, H.; *Wang, X. “Small Molecule Modulators of Toll-Like Receptors”, Acc. Chem. Res. 2020, 53, 1046-1055 (cover article).
6.      Jiang, S.; Tanji, H.; Yin, K.; Zhang, S.; Sakaniwa, K.; Huang, J.; Yang, Y.; Li, J.; Ohto, U.; Shimizu, T.; *Yin, H. “Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface”, J. Med. Chem. 2020, 63, 4117-4132
7.      Gao, M.; Huang, J.; Jiang, X.; Yuan, Y.; Luo, S.; Wang, N.; Pang, H.; Deng, D.; Yao, C.; Lin, Z.; Pu, D.; Liu, Z.; Hu, Z.; *Yin, H. “Regulation of Aerobic Glycolysis to Decelerate Tumor Proliferation by Small Molecule Inhibitors Targeting Glucose Transporters”, Protein Cell 2020, 11, 446-451.
8.      Zhang, Y.; Jin, X.; Liang, J.; Guo, Y.; Sun, G.; Zeng, X.; *Yin, H. “Extracellular Vesicles Derived from ODN-Stimulated Macrophages Promote Their Cellular Uptake by the Transfer and Activation of Cdc42”, Sci. Adv. 2019, 5, eaav1564.
9.      Padilla-Salinas, R.; Anderson, R.; Sakaniwa, K.; Zhang, S.; Nordeen, P.; Lu, C.; Shimizu, S.; *Yin, H. “Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptor 7 and 8”, J. Med. Chem. 2019, 62, 10221-10244.
10.   Tamura, R.; Balabanova, A.; Frakes, S. A.; Bargmann, A.; Koch, T. H.; *Yin, H. “Photoactivatable Prodrug of Doxazolidine Targeting Exosomes”, J. Med. Chem. 2019, 62, 1959-1970.
11.   Hu, Z.; Tanji, H.; Jiang, S.; Zhang, S.; Koo, K.; Chan, J.; Sakaniwa, K.; Ohto, U.; Candia, A.; Shimizu, T.; *Yin, H. “Small Molecule TLR8 Antagonists via Structure-Based Rational Design”, Cell Chem. Biol. 2018, 25, 1286-1291 (cover article).
12.   Bhattacharyya, S.; Wang, W.; Qin, W.; Cheng, K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.; Tamaki, Z.; *Yin, H.; *Varga, J. “TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skin and Lung”, JCI Insight 2018, 3, e98850 (featured in “News & ViewsNat. Rev. Rheumatol. 2018, 14, 564-566).
13.   Zhang, L.; Shi, L.; Soars, S. M.; Kamps, J.; *Yin, H. “Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Anti-Inflammatory and Anti-Cancer Properties”, J. Med. Chem. 2018, 61, 5881-5899.
14.   Zhang, S.; Hu, Z.; Tanji, H.; Jiang, S.; Das, N.; Li, J.; Sakaniwa, K.; Jin, J.; Bian, Y.; Ohto, U.; Shimizu, T.; *Yin, H. “Small Molecule Inhibition of TLR8 through Stabilization of Its Resting State”, Nat. Chem. Biol. 2018, 14, 58-64 (cover article; featured as C&EN “Latest News”).
15.   Zhang, L.; Dewan, V.; *Yin, H. “Discovery of Small Molecules as Multi-TLR Agonists with Proinflammatory and Anticancer Activities”, J. Med. Chem. 2017, 60, 5029-5044.
16.   Smith, C. E.; Soti, S.; Jones, T. A.; Nakagawa, A.; Xue, D.; *Yin, H. “NSAIDs are Caspase Inhibitors”, Cell Chem. Biol. 2017, 24, 281-292 (featured in “ConcentratesC&EN 2017, 95(10), 10; NIH Research Matters; The Sun; Daily Mail; WebMD).
17.   Das, N.; Dewan, V.; Grace, P. M.; Rosenfeld-Gunn, R. J.; Tamura, R.; Tzarum, N.; Watkins, L. R.; Wilson, I. A.; *Yin, H. “HMGB-1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia”, Cell Rep. 2016, 17, 1128-1140.
18.   *Yin, H.; Flynn, A. D. “Drugging Membrane Protein Interactions”, Annu. Rev. Biomed. Eng. 2016, 18, 51-76.
19.   Daniele, S. G.; Beraud, D.; Davenport, C.; Cheng, K.; *Yin, H.; *Maguire-Zeiss, K. A. “Activation of MyD88-Dependent TLR1/2 Signaling by Misfolded α-Synuclein, a Protein Linked to Neurodegenerative Disorders”, Sci. Signal. 2015, 8, ra45 (highlighted in “This Week in ScienceScience 2015, 348, 769; Podcast: Maguire-Zeiss, K. A.; Daniele, S. G.; Yin, H.; VanHook, A. M.; Sci. Signal. 2015, 8, pc12).      
20.   Cheng, K.; Gao, M.; Godfroy III, J. I.; Brown, P. N.; Kastelowitz, N.; *Yin, H. “Specific Activation of the TLR1-TLR2 Heterodimer by Small-molecule Agonists”, Sci. Adv. 2015, 1, e1400139 (featured in “Science & TechnologyC&EN 2015, 93(15), 39-40; The Pharmaceutical Journal News).
Smith, C. E.; Wang, X. H.; *Yin, H. “Caspases Come Together Over LPS”, Trends Immunol. 2015, 36, 59-61.